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Saturday, February 4th 2012 |
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CMSB Structure
The CMSB operates under general directorship of Professor dr. Gert-Jan B. van Ommen (LUMC).
Dr. Frans van der Touw (LUMC) is administrative manager. The CMSB research is structured in five complementary research platforms:
The first two platforms have their main emphasis on the discovery phase of our reseach. The next two platforms focus on the validation phase, and the clinical platform aims at the translational phase, where clinical trials are performed. The DIAL platform has a coordinating function and the societal platform has as its focus the effects of public implementation of innovative medical knowledge and treatments.  Epidemiology
Coordinators: Prof dr Cornelia M. van Duijn (EMC) and Prof dr Peter Heutink (VUmc)
Goals: To collect, catalogue and store clinical data and biological material of patient cohorts and control populations; to facilitate, coordinate and oversee their usage in the CMSB; to integrate and expand existing equipment and methodology for high-throughput haplotying; to develop education in molecular/statistical epidemiology. Systems Biology
Coordinators: Prof dr Jan van der Greef (TNO) and Prof dr Guus A.B. Smit (VU)
Goals: To generate and integrate high-density quantitative data from gene expression and -dosage analysis, proteomics and metabolomics; to coordinate use of existing and acquisition of new methodology and equipment for high-throughput automated analysis; to study disease loci for their mechanistic contribution to initiation and progression of complex disease; to facilitate information exchange and develop education in the various areas of systems biology. Technology
Coordinator: Prof dr Huub J.M. de Groot (UL)
Goals: To design and apply methodology for the assays of biomolecular interactions; to develop in vitro and cellular functional screens for pathway identification and target validation; to determine structures and ligand binding properties of newly identified proteins; to implement high-resolution in vivo magnetic resonance microscopy (MRM) for animal models; to facilitate information exchange and develop education in genomics technology. Model Systems
Coordinator: Prof dr Rune R. Frants (LUMC)
Goals: To coordinate and where possible integrate animal experimentation for gene discovery; to establish animal functional screens for pathway identification and target validation; to expand existing and implement new methodology for conditional mouse models, RNAi approaches and in vivo real-time imaging and spectroscopy, using magnetic resonance and luminiscence. Clinical Applications
Coordinator: Prof dr Cornelis J.M. Melief (LUMC)
Goals: To integrate insights and deliverables from the above projects in the improvement of diagnostics, prognostics, and therapy; to identify and validate molecular targets for therapy and prophylaxis in human and animal studies; to deliver proof-of-principle for new therapeutic strategies; to assist industrial partners in preclinical and epidemilogical toxicology studies and drug validation; to facilitate information exchange and develop education in the impact of genomics in health care, both to professionals and the larger public. Data Integration, Analysis and Logistics (DIAL)
Coordinator: Dr J.H van Beek (VUmc)
Goals: To interface local databases; to establish a central database for experimental information; to develop biostatistics for the interlinking of Epidemiological and Systems Biology approaches; to implement commercial and develop in-house bioinformatics for the internal and external data mining and integration of all projects; to collaborate, within the BioASP framework, on the development of biostatistics, bioinformatics and GRID-based Virtual Laboratory Software; to develop education in biostatistics and bioinformatics. Website: dial.liacs.nl Societal Aspects of Genomics (MAG-CMSB)
Coordinator: Prof dr. Martina C. Cornel (VUmc)
Goals: To study ethical, legal, psychological and societal aspects of genomics applications in the field of complex diseases; to study the implementation of genetic screening and help to identify ways to proceed with further implementation; to develop education and stimulate debate on societal aspects of genomics; to create a multidisciplinary network of experts that know the past and present debate on valorisation and implementation of genomics applications in Dutch healtcare, especially in the domain of preventive medicine. Relevant links for Societal aspects of health genomics Leiden Muscular Dystrophy pages Department of Medical Decision Making, LUMC EMGO institute, VUmc TNO kwaliteit van leven, afd. preventie en zorg Department of Public Health ErasmusMC Department of Clinical Genetics ErasmusMC Department of Medical Psychology and Psychotherapy ErasmusMC Prof W. Drees, Faculty of Theology, Leiden University Center for Society and Genomics - CSG Cancer Genomics Center - CGC Center for Biosystems Genomics Kluyver Center Wat is genomics |
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